Bitdefender USB Immunizer is a simple tool that can reduce that chance of your USB flash drive becoming infected by autorun-based malware.
Under normal circumstances this can happen very easily. All you need to do is plug your drive into an infected PC, and the malware will copy itself to the device, adding a custom autorun.inf file. When you next connect the drive to a system where autorun is enabled, the malware will be launched, and that PC will become infected, too.
Use Bitdefender USB Immunizer, though, and the program will create an Autorun.inf folder on your PC, which in turn contains a number of other files.
If malware tries to create an Autorun.inf file on the drive,
then the operation will fail (you can't have an \Autorun.inf file if there's already a folder there with the same name).